Annual report pursuant to Section 13 and 15(d)

11. Warrants (Details Narrative)

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11. Warrants (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Gross proceeds from exercise of warrants $ 3,866,573  
Warrant [Member]    
Warrants outstanding 3,414,389 1,651,698
Reload Warrants [Member]    
Warrants issued 799,991  
Market Price Warrants [Member]    
Warrants issued 371,699  
Private Transaction [Member]    
Gross proceeds from exercise of warrants $ 3,866,573  
Fair value of warrants issued $ 1,402,174  
Stock issued new, shares 1,171,689  
Private Transaction [Member] | Chardan [Member]    
Payment of stock issuance costs $ 363,617  
Private Transaction [Member] | New Warrants [Member] | Chardan [Member]    
Warrants issued 115,000  
Direct Offering [Member]    
Warrants issued 1,647,691  
Stock issued new, shares 1,647,691  
Gross proceeds from sale of equity $ 6,425,995