Annual report pursuant to Section 13 and 15(d)

13. Warrants (Details Narrative)

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13. Warrants (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Gross proceeds from exercise of warrants   $ 3,866,573  
Warrants issued 930,001    
Fair value of warrants issued $ 1,471,111    
Warrant [Member]      
Warrants outstanding 5,899,389 3,414,389 1,651,698
Reload Warrants [Member]      
Warrants issued   799,991  
Market Price Warrants [Member]      
Warrants issued   371,699  
Private Transaction [Member]      
Gross proceeds from exercise of warrants   $ 3,866,573  
Fair value of warrants issued   $ 1,402,174  
Stock issued new, shares   1,171,689  
Private Transaction [Member] | Chardan [Member]      
Payment of stock issuance costs   $ 363,617  
Private Transaction [Member] | New Warrants [Member] | Chardan [Member]      
Warrants issued   115,000  
Direct Offering [Member]      
Warrants issued   1,647,691  
Stock issued new, shares   1,647,691  
Gross proceeds from sale of equity   $ 6,425,995  
January 2018 Private Placement [Member]      
Warrants issued 685,000